Game Details:
Matchup: Jaguars (10-5) vs Colts (9-6)
Date & Time: Saturday, December 27, 2025 | 8:15 PM ET
Venue: Lucas Oil Stadium, Indianapolis, IN
Betting Line: Colts -1.5 | Over/Under: 44.5
Key Storylines
AFC South Title Race Heats Up: With just two weeks remaining in the NFL regular season, tonight’s clash between the Jaguars and Colts could very well decide the AFC South. Jacksonville currently holds a one-game lead over Indianapolis, making this tilt a must-win for the home side.
Late-Season Momentum: The Colts come into this matchup riding high after a three-game win streak, most recently upsetting the Chiefs 23-17 on the road in Week 16. Quarterback Anthony Richardson has been showing steady growth in his rookie season and looks more comfortable week-to-week. The Jaguars, on the other hand, suffered a tough 27-24 loss at home to the Ravens and need to dial things in quickly to avoid a potential collapse down the stretch.
Injury Report
Jaguars:
Out: WR Christian Kirk (core muscle), CB Tyson Campbell (hamstring)
Questionable: QB Trevor Lawrence (ankle), RB Travis Etienne Jr. (ribs)
Colts:
Out: RB Jonathan Taylor (ankle), CB JuJu Brents (quad)
Questionable: WR Michael Pittman Jr. (concussion protocol)
Betting Trends
Against the Spread (ATS):
Jaguars: 7-8 ATS this season
Colts: 9-6 ATS
Over/Under Trends:
The total has gone under in 9 of Jacksonville’s 15 games
The total has gone over in 10 of Indianapolis’ 15 games
Home Field Advantage:
The Colts are 5-2 at home this year and have proven hard to beat under the dome. Meanwhile, the Jaguars are just 4-3 on the road and haven’t played particularly well indoors.
Player Props to Watch
Anthony Richardson (Colts) – Rushing Yards Total: 46.5
The Jaguars defense has struggled against mobile quarterbacks. Richardson may find success both through the air and on the ground, making his rushing prop worth a shot.
Evan Engram (Jaguars) – Receptions Total: 5.5
With injuries limiting Jacksonville’s weapons, Engram has become a safety valve for Lawrence. He’s hit the over in 3 of the last 4 games.
Prediction & Best Bets
Spread: Colts -1.5 → Indianapolis has more momentum and home-field support.
Total: Under 44.5 → Both teams have injury concerns, and red zone production has been inconsistent.
Player Prop: Anthony Richardson Over 46.5 rushing yards → Jacksonville’s defense ranks near the bottom against QB runs.
This is as close to a playoff game as it gets in Week 17. While the Jaguars have been more consistent throughout the year, the Colts’ recent form and the tough environment in Lucas Oil tilt the balance. If Richardson continues making plays and the defense capitalizes on Jacksonville’s banged-up offense, Indy should emerge with the win.
Final Score Prediction: Colts 24, Jaguars 20
