Game Details:
Matchup: Cardinals vs Cowboys
Date & Time: Monday, November 3, 2025 | 8:15 PM ET
Venue: AT&T Stadium, Arlington, TX
Betting Line: Cowboys -7.5 | Over/Under: 44.5
Key Storylines
Prescott vs Murray: Quarterback Duel in Prime Time
All eyes will be on the quarterback matchup between Dak Prescott and Kyler Murray. Prescott is leading one of the most efficient offenses in the league this season, while Murray, in his second full year back from injury, is trying to reassert himself as a premier dual-threat threat. Both QBs have shown flashes this season, but consistency has plagued Murray and the Cardinals offense.
Cowboys’ Home Dominance
The Cowboys have been dominant at home, boasting a 4-0 record at AT&T Stadium this season. Their defense, led by Micah Parsons, has created pressure and turnovers regularly, especially in front of a fired-up home crowd. Arizona’s offensive line will need to be at their best to contain the relentless Cowboys front.
Cardinals’ Inconsistent Defense
Arizona’s defense has struggled throughout the season, particularly against the run. This could spell trouble as Cowboys running back Tony Pollard looks to bounce back after a slow start to the year. The Cardinals have allowed over 140 rushing yards per game, ranking near the bottom of the league.
Injury Report
Cardinals:
Questionable: James Conner (ankle), Budda Baker (hamstring), Paris Johnson Jr. (shoulder)
Out: Zaven Collins (knee)
Cowboys:
Questionable: Tyron Smith (neck), CeeDee Lamb (knee)
Out: Leighton Vander Esch (IR), Rico Dowdle (ankle)
Betting Trends
Against the Spread (ATS):
- Cardinals: 3-5 ATS in 2025 season
- Cowboys: 6-2 ATS in 2025 season
Over/Under Trends:
- The total has gone OVER in 5 of the Cowboys’ last 7 games
- Cardinals games have hit the OVER in 6 of 8 contests this year
Player Prop to Watch
CeeDee Lamb (Cowboys) – Receiving Yards Total: 81.5
Lamb has topped 80 yards in four of his last five games, emerging as Prescott’s most consistent target. If he’s active, the over is worth watching against a porous Cardinals secondary.
James Conner (Cardinals) – Rushing Yards Total: 56.5
If healthy, Conner could be relied on to control the clock. However, facing a top-5 run defense on the road dims his value. The under may be a play here.
Prediction & Best Bets
- Spread: Cowboys -7.5 → With a well-rounded defense and more consistency on offense, Dallas should cover comfortably at home.
- Total: Over 44.5 → Both teams have trended over, and garbage-time points from Arizona could push the total over.
- Player Prop: CeeDee Lamb Over 81.5 receiving yards → Prescott will look his way often, and Arizona doesn’t have the secondary to stop him.
The Cardinals might keep it close early, but expect the Cowboys to pull away in the second half behind a balanced attack and fierce front seven on defense.
Final Score Prediction: Cowboys 31, Cardinals 20
